Finding natural compounds as potential inhibitors for osteoarthritis
By: Shah, F. H
.
Contributor(s): Eom, Y. S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(5), Sep-Oct.Description: 1227-1232p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Osteoarthritis is the fourth leading cause of disability affecting more than 300 million people around the
globe. In this disease, chondrocytes responsible for the growth and maintenance of articular joints start
to deplete due to the rogue involvement of phosphoinositide 3-kinase, protein kinase-B and p38 mitogen-
activated protein kinases. Presently, there are medications providing symptomatic treatment, however,
they cannot thwart the progression of osteoarthritis. Natural compounds can rejuvenate injured tissues,
averting inflammation and can be useful for treating osteoarthritis. The present study was conducted
to obtain inhibitors using natural compounds for phosphoinositide 3-kinase/protein kinase-B/mitogen-
activated protein kinases implicated in the pathogenesis of osteoarthritis. Results revealed that out of
1541 natural compounds, cordycepin and geraniol formed an inhibitory interaction with these kinases.
Moreover, these compounds down regulated important inflammatory markers (DNA methyltransferase 1,
cluster of differentiation 74 and ETS proto-oncogene 1) and increased the expression of glutamate-cysteine
ligase catalytic, FAM111 trypsin like peptidase A, secreted frizzled related protein 1 and ferritin light chain
genes implicated in the survival of chondrocytes. The absorption, distribution, metabolism, excretion,
toxicity and lethal dose prediction studies showed that cordycepin has appropriate pharmacokinetics
and low acute toxicity level, whereas geraniol has high toxicity level and efficient pharmacokinetic
profile. Our study provided a preliminary insight that cordycepin and geraniol are capable inhibitors of
phosphoinositide 3-kinase/protein kinase-B/mitogen-activated protein kinases and can be lead compounds
in osteoarthritis therapy.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-1134 |
Osteoarthritis is the fourth leading cause of disability affecting more than 300 million people around the
globe. In this disease, chondrocytes responsible for the growth and maintenance of articular joints start
to deplete due to the rogue involvement of phosphoinositide 3-kinase, protein kinase-B and p38 mitogen-
activated protein kinases. Presently, there are medications providing symptomatic treatment, however,
they cannot thwart the progression of osteoarthritis. Natural compounds can rejuvenate injured tissues,
averting inflammation and can be useful for treating osteoarthritis. The present study was conducted
to obtain inhibitors using natural compounds for phosphoinositide 3-kinase/protein kinase-B/mitogen-
activated protein kinases implicated in the pathogenesis of osteoarthritis. Results revealed that out of
1541 natural compounds, cordycepin and geraniol formed an inhibitory interaction with these kinases.
Moreover, these compounds down regulated important inflammatory markers (DNA methyltransferase 1,
cluster of differentiation 74 and ETS proto-oncogene 1) and increased the expression of glutamate-cysteine
ligase catalytic, FAM111 trypsin like peptidase A, secreted frizzled related protein 1 and ferritin light chain
genes implicated in the survival of chondrocytes. The absorption, distribution, metabolism, excretion,
toxicity and lethal dose prediction studies showed that cordycepin has appropriate pharmacokinetics
and low acute toxicity level, whereas geraniol has high toxicity level and efficient pharmacokinetic
profile. Our study provided a preliminary insight that cordycepin and geraniol are capable inhibitors of
phosphoinositide 3-kinase/protein kinase-B/mitogen-activated protein kinases and can be lead compounds
in osteoarthritis therapy.
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